Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, play pivotal roles in regulating gene expression without altering the underlying DNA sequence. These modifications are crucial during human development, influencing cell differentiation and organogenesis. Disruptions in epigenetic regulation can lead to various developmental disorders, such as Rett syndrome, Fragile X syndrome, and Beckwith-Wiedemann syndrome. This article delves into the mechanisms of epigenetic regulation, explores their roles in human development, and examines how their dysregulation contributes to developmental disorders. Understanding these processes offers potential avenues for therapeutic interventions and highlights the importance of epigenetics in human health.