Plant-Derived Natural Antifungal Agents: Evaluation of Candida species Susceptibility in a Comprehensive Review
Abstract
This comprehensive review examines the antifungal activity of natural plant extracts against Candida species (Candida spp.), especially with their increasing resistance to conventional drugs like azoles and echinocandins. The research includes an analysis of active plant compounds such as terpenoids, phenols, alkaloids, and flavonoids, and their mechanisms of action, including cell membrane disruption, inhibition of biofilm formation, and induction of oxidative stress. It also discusses the variation in sensitivity among different species, with a particular focus on C. albicans, C. glabrata, and C. auris, and the importance of standardized laboratory testing. The research addresses drug synthesis strategies, and toxicological and pharmacokinetic considerations, emphasizing the need for safety evaluation and standardization to promote the use of plant-based alternatives in the face of resistant fungal infections.
How to Cite This Article
Noor Ahmed Shehab Alhealy, Omaema Nawfal Ahmed, Zena Yehea Kassim Al-Hasso (2026). Plant-Derived Natural Antifungal Agents: Evaluation of Candida species Susceptibility in a Comprehensive Review . International Journal of Biological and Biomedical Research (IJBBMR), 2(4), 01-10. DOI: https://doi.org/10.54660/IJBBR.2026.2.4.01-10